Product ID:CHLORAMPHENICOL, 220551
MSDS Date:02/15/1999
FSC:6550
NIIN:00N092480
Status Code:A
MSDS Number: CJTBW

Emergency Phone: 202-783-7616 (INTERNATL)

Info Phone: 800-854-3417; 619-450-5558

Cage: 29089

Telephone: 619-450-5558; 800-854-3417

Cage: 29089

CHLORAMPHENICOL

CAS: 56-75-7

RTECS: AB6825000

LD50 LC50 Mixture:LD50:(ORAL,RAT) 2500 MG/KG & TOX INFO.
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:YES OSHA:NO
Health Hazards Acute and Chronic:ACUTE EFFECTS: MAY BE HARMFUL BY
INGESTION, INHALATION OR ABSORPTION THRU SKIN. EXPOSURE TO MATERIAL
MAY CAUSE SENSITIZATION. PROLONGED EXPOSURE MAY CAUSE
CARDIOVASCULAR COLLAPSE. MATERIAL MAY CAUSE D EPRESSION OF BONE
MARROW, LEADING TO APLASTIC ANEMIA. THIS CONDITION MAY PROGRESS TO
ACUTE MYELOBLASTIC LEUKEMIA. CHRONIC EFFECTS: THERE IS LTD EVIDENCE
THAT CHLORAMPHENICOL IS TERATOGENIC AND TUMORIG ENIC IN LABORATORY
ANIMALS. THERE IS ALSO LIMITED EVIDENCE THAT CHLORAMPHENICOL IS
MUTAGENIC IN LABORATORY CELL CULTURES. UNTIL FURTHER TESTING HAS
BEEN DONE, IT SHOULD BE TREATED AS A POSSIBLE TERATO GEN, MUTAGEN,
AND TUMORIGEN IN HUMANS.
Explanation of Carcinogenicity:CHLORAMPHENICOL: IARC MONOGRAPHS ON THE
EVALUATION OF CARCINOGENIC RISKS OF CHEMICALS TO MAN, VOLUME 50,
PAGE 169, 1990: GROUP 2A.
Effects of Overexposure:SEE HEALTH HAZARDS.

First Aid:SKIN: WASH IMMEDIATELY WITH SOAP AND COPIOUS AMOUNTS OF WATER
FOR AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND SHOES AND
WASH BEFORE WEARING. CONSULT MD. EYES: FLUSH IMMEDIATELY WITH
COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE
FLUSHING BY SEPARATING EYELIDS WITH FINGERS. CONSULT MD.
INHALATION: REMOVE TO FRESH AIR AND MONITOR BREATHING. IF BREATHING
BECOMES DIFFICULT , GIVE OXYGEN AND CONSULT MD. IF BREATHING STOPS,
GIVE ARTIFICIAL RESPIRATION AND CONSULT MD. INGESTION: WASH MOUTH
OUT WITH WATER AND CONSULT LOCAL POISON CENTER AND MD.

Extinguishing Media:DRY CHEMICAL POWDER, CARBON DIOXIDE, WATER SPRAY,
ALCOHOL OR POLYMER FOAM.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA AND FULL PROTECTIVE
EQUIPMENT .
Unusual Fire/Explosion Hazard:UPON THERMAL DECOMPOSITION, IT MAY EMIT
TOXIC GASES.

Spill Release Procedures:EVACUATE AREA. WEAR A NIOSH APPROVED
RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS AND HEAVY RUBBER
GLOVES. SWEEP UP AND PLACE IN A SUITABLE CONTAINER. AVOID RAISING
DUST. HOLD FOR APPROPRIATE DIS POSAL. WASH SPILL SITE AND VENTILATE
AREA AFTER MATERIAL PICKUP IS COMPLETE.

Handling and Storage Precautions:STORE IN A TIGHTLY CLOSED CONTAINER IN
A COOL, DRY PLACE (+20C). MATERIAL IS HARMFUL. MAY CAUSE
SENSITIZATION. POSSIBLE TERATOGEN, MUTAGEN AND TUMORIGEN. AVOID
CONTACT WITH MATERIAL. AVOID PROLONGED O R REPEATED EXPOSURE. DO
NOT BREATHE DUST. AVOID CONTACT WITH SKIN AND EYES.
Other Precautions:MAY CAUSE CANCER. MAY CAUSE HERITABLE GENETIC DMG.
MAY CAUSE BIRTH DEFECTS. DANGER OF SERIOUS DMG TO HEALTH BY
PROLONGED EXPOS. IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK
MED ADVICE IMMED. AVOID EXPOS-OBTAIN SPECIAL INSTRUCTIONS BEFORE
USE. MATERIAL SHOULD ONLY BE HANDLED BY QUALIFIED, EXPERIEN CED
PROFESSIONALS.

Respiratory Protection:USE A NIOSH APPROVED RESPIRATOR.
Ventilation:HANDLE IN A CHEMICAL FUME HOOD WITH ADEQUATE VENTILATION.
Protective Gloves:CHEMICAL RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES & FULL LENGTH
FACESHIELD .
Other Protective Equipment:ANSI APPROVED EYE WASH & DELUGE SHOWER .
WEAR SUITABLE PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING MATERIAL.
Supplemental Safety and Health
MFR'S INFO: MFR'S FAX #: (619) 452-3552. MFR'S INFO ON INGS: MOLECULAR
WEIGHT: 323.1. MOLECULAR FORMULA: C*11H*12CL*2N*2O*5. -- PHYSICAL
AND CHEMICAL PROPERTIES: SOLUBILITY: SOLUBLE IN ETHANOL AND MET
HANOL.

Melt/Freeze Pt:>149.C, 300.2F
M.P/F.P Text:149-154C
Solubility in Water:SOLUBLE & SUPP DATA
Appearance and Odor:GREYISH-WHITE SOLID.

Stability Indicator/Materials to Avoid:YES
AVOID CONTACT WITH ACIDS, ACID CHLORIDES, ACID ANHYDRIDES, AND
OXIDIZING AGENTS.
Stability Condition to Avoid:STABLE UNDER NORMAL HANDLING PROCEDURES.
Hazardous Decomposition Products:UPON THERMAL DECOMPOSITION, MAY EMIT
TOXIC GASES INCLUDING CARBON MONOXIDE, CARBON DIOXIDE, NITROGEN
OXIDES AND HYDROGEN CHLORIDE GAS.

Waste Disposal Methods:COUNTRY, FEDERAL, STATE AND LOCAL REGULATIONS
ARE VARIED AND CHANGE FREQUENTLY. FOR THIS REASON, MFR RECOMMENDS
THAT YOU CONTACT YOUR LOCAL DEPARTMENT OF HEALTH SERVICES FOR
INFORMATION ON THE DISPOSA L OF THIS PRODUCT OR ARRANGE FOR
DISPOSAL BY A LICENSED DISPOSAL COMPANY.

Toxicological Information:TOX DATA & REFERENCES: ORL; INF; TDLO; 440
MG/KG SOMNOLENCE; BODY TEMP CHANGES; GI EFTS 1975; ORL; WMN; LDLO:
400 MG/KG COMA; SHOCK; CYANOSIS 1975. "JAMA, JOURNAL OF AMERICAN
MED ASSOC". 234, 149. LD5 0:(ORL,RAT) 2500 MG/KG 1955;
LD50:(ORL,GPG) 500 MG/KG 1955. "FARMACO, EDIZONE SCIENTIFICA". 10,
3. LD50:(ORL,MUS) 1500 MG/KG 1955. "ARZNEIMITTEL-FORSCHUNG. DRUG
RESEARCH". 5, 1. IVN; INF; LDLO: 30 MG/ KG/3D-1 CARDIAC OUTPUT, BP
LOWERING 1983. "JOURNAL OF PEDIATRICS". 103, 487. LD50:(IVN,RBT)
117 MG/KG 1949. "JOURNAL OF CLINICAL INVESTIGATION". 28, 943. IMS;
INF; TDLO: 250 MG/KG/2D CHANGE IN PLASMA/ BLOOD VOL 1960. "NEW
(ECOLOGICAL INFO)

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:NO INFO AVAIL. -- TOX INFO: ENGLAND JOURNAL OF MEDICINE".
26, 787. UNR; CHD; TDLO: 250 MG/KG/10D HEMORR; CHANGE IN BONE
MARROW; LIVER EFTS 1975. "CLINICAL PEDIATRICS (PHILADELPHIA)". -14,
499. UNR; IN F; LDLO: 200 MG/KG/4D-1 CONVLS; EOSINOPHILIA; DERM
1986. "LANCET". 103, 487. REPRO EFTS & REFERENCES: ORL; RAT; DOSE:
2500 MG/KG CNS DEVEL ABNORMS 1971; ORL; RAT; DOSE: 2500 MG/KG FETAL
DEATH 1971 "AR KHIV ANATOMII, GISTOLOGII I EMBRIOLOGII. ARCHIVES OF
ANATOMY, HISTOLOGY & EMBRYOLOGY". 60(5), 25. ORL; RAT; DOSE: 2 G/KG
FETOTOXICITY; FETAL DEATH; BODY WALL DEVEL ABNORMS 1971; ORL; RBT;
DOSE: 4 G/KG FETOTOXICITY; FETAL (TRANSPORT INFO)

Transport Information:UN #:N/A. PROPER SHIPPING NAME:N/A. IATA
CLASS:N/A. IATA PACKING GRP:N/A. -- ECOLOGICAL INFO: DEATH 1971;
ORL; RBT; DOSE: 4 G/KG MUSCULOSKELETAL SYS DEVEL ABNORMS 1971.
"TOXICOLOGY & APPLIED PHARMACOL OGY". 19 667. ORL; MUS; DOSE: 175
MG/KG TOX EFTS TO NEWBORN 1974. "NEUROPHARMACOLOGY". 13, 233.
GENETIC DATA & REFERENCES: LNG; RAT; DOSE: 4 MMOL/L DNA DMG 1991;
LVR; RAT; DOSE: 2 MMOL/L DNA DMG 1991; LVR; HMN; DOSE: 1 MMOL/L
UNSCHEDULED DNA SYNTHESIS 1991; LVR; RAT DOSE: 2 MMOL/L UNSCHEDULED
DNA SYNTHESIS 1991; LYM; HMN; DOSE: 1 MMOL/L DNA INHIBITION 1994;
HLA; RAT; DOSE: 1 G/KG BODY FLUID ASSAY 1967. "MUTATION (SARA
TITLE III)

SARA Title III Information:N/P --TRANSPORT INFO: RESEARCH". 4, 874.
LVR; RAT; DOSE: 1600 UMOL/L DNA REPAIR 1989. "ZHONGGUO YAOLI
ZUEBAO. ACTA PHARMACOLOGICA SINICA. CHINESE JOURNAL OF
PHARMACOLOGY". 10, 543. BMR; HMN; DOSE: 150 0 UMOL/L DNA INHIBITION
1981. " 'SFTY PROBS RELATED TO CHLORAMPHENICOL & THIAMPHENICOL
THERAPY,' NAJEAN, Y., ET AL., EDS., NEW YORK, RAVEN PRESS". -, 17.
LEU; HMN; DOSE: 100 MG/L CYTOGENETIC ANALYSIS 1973. "CANCER
RESEARCH". 33, 1829. LYM; HMN; DOSE: 500 MG/L CYTOGENETIC ANALYSIS
1969. "HUMANGENETIK". 7, 305. EMB; HAM; DOSE: 30 MG/L SISTER
CHROMATID EXCHANGE 1987. "SHIGAKU. ONDOTOLOGY". 74, 1385.
TUMORIGENIC DATA & (STATE REG INFO)
Federal Regulatory Information:REGULATORY INFO: T; XI. RISK PHRASES:
R20/21/22: HARMFUL BY INHAL, IN CONT WITH SKIN & IF SWALLOWED.
R42/43: MAY CAUSE SENSIT BY INHAL & SKIN CONT. R45: MAY CAUSE
CANCER. R46: MAY CAUSE HERITABLE GENE TIC DMG. R47: MAY CAUSE BIRTH
DEFECTS. R48: DANGER OF SERIOUS DMG TO HLTH BY PRLNG EXPOS. SAFETY
PHRASES: S22: DO NOT BREATHE DUST. S24/25: AVOID CONT WITH SKIN &
EYES. S26: IN CASE OF CONT WITH EYES, RINSE IMMED WITH PLENTY OF
WATER & SEEK MED ADVICE. S36/37/39: WEAR SUITABLE PROT CLTHG,
GLOVES & E YE/FACE PROT. S45: IN CASE OF ACCIDENT/IF YOU FEEL
UNWELL, SEEK MED ADVICE IMMED. S53: AVOID EXPOS-OBTAIN SPECIAL
INSTRUCTIONS BEFORE USE.
State Regulatory Information:N/P --SARA TITLE III: REFERENCES: ORL;
MAN; DOSE: 434 MG/KG/W-C CARCINOGENIC BY RTECS CRITERIA; APLASTIC
ANEMIA; LEUKEMIA 1981. "ACTA HAEMATOLOGICA". 66, 267. ORL; WMN;
DOSE: 300 MG/KG/60W-1 CARCINOGE NIC BY RTECS CRITERIA; CHANGES IN
BONE MARROW; LEUKEMIA 1967; ORL; WMN; DOSE: 1680 MG/KG 6W-1
CARCINOGENIC BY RTECS CRITERIA; APLASTIC ANEMIA; LEUKEMIA 1967.
"NEW ENGLAND JOURNAL OF MEDICINE". 277, 10 03. REVIEWS: IARC CANCER
REVIEW: ANIMAL INADEQUATE EVID 1976; HUMAN LTD EVID 1976. "IARC
MONOGRAPHS ON EVAL OF CARCINOGENIC RISK OF CHEMS TO MAN". 10, 85.
IARC CANCER REVIEW: ANIMAL INADEQUATE EVID 1990; GRP 2A 1990; HUMAN
(OTHER INFO)